WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: .05, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Tight junction       ID:04530
C=132; O=10; E=0.88; R=11.34; rawP=2.30e-08; adjP=1.43e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166025 NA AMOTL1 angiomotin like 1 154810 ENSG00000166025
2  ENSG00000102981 NA PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 50855 ENSG00000102981
3  ENSG00000183230 NA CTNNA3 catenin (cadherin-associated protein), alpha 3 29119 ENSG00000183230
4  ENSG00000158186 NA MRAS muscle RAS oncogene homolog 22808 ENSG00000158186
5  ENSG00000104067 NA TJP1 tight junction protein 1 7082 ENSG00000104067
6  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
7  ENSG00000151276 NA MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 9223 ENSG00000151276
8  ENSG00000133818 NA RRAS2 related RAS viral (r-ras) oncogene homolog 2 22800 ENSG00000133818
9  ENSG00000091436 NA ZAK sterile alpha motif and leucine zipper containing kinase AZK 51776 ENSG00000091436
10  ENSG00000101608 NA MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 10627 ENSG00000101608


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=10; E=1.42; R=7.03; rawP=1.96e-06; adjP=4.61e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113578 NA FGF1 fibroblast growth factor 1 (acidic) 2246 ENSG00000113578
2  ENSG00000138443 NA ABI2 abl-interactor 2 10152 ENSG00000138443
3  ENSG00000129675 NA ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 9459 ENSG00000129675
4  ENSG00000158186 NA MRAS muscle RAS oncogene homolog 22808 ENSG00000158186
5  ENSG00000154380 NA ENAH enabled homolog (Drosophila) 55740 ENSG00000154380
6  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
7  ENSG00000035403 NA VCL vinculin 7414 ENSG00000035403
8  ENSG00000133818 NA RRAS2 related RAS viral (r-ras) oncogene homolog 2 22800 ENSG00000133818
9  ENSG00000101608 NA MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 10627 ENSG00000101608
10  ENSG00000165410 NA CFL2 cofilin 2 (muscle) 1073 ENSG00000165410


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=11; E=1.79; R=6.15; rawP=2.23e-06; adjP=4.61e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113578 NA FGF1 fibroblast growth factor 1 (acidic) 2246 ENSG00000113578
2  ENSG00000128591 NA FLNC filamin C, gamma 2318 ENSG00000128591
3  ENSG00000112658 NA SRF serum response factor (c-fos serum response element-binding transcription factor) 6722 ENSG00000112658
4  ENSG00000158186 NA MRAS muscle RAS oncogene homolog 22808 ENSG00000158186
5  ENSG00000011566 NA MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 8491 ENSG00000011566
6  ENSG00000135341 NA MAP3K7 mitogen-activated protein kinase kinase kinase 7 6885 ENSG00000135341
7  ENSG00000133818 NA RRAS2 related RAS viral (r-ras) oncogene homolog 2 22800 ENSG00000133818
8  ENSG00000091436 NA ZAK sterile alpha motif and leucine zipper containing kinase AZK 51776 ENSG00000091436
9  ENSG00000153956 NA CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 781 ENSG00000153956
10  ENSG00000142875 NA PRKACB protein kinase, cAMP-dependent, catalytic, beta 5567 ENSG00000142875
11  ENSG00000135090 NA TAOK3 TAO kinase 3 51347 ENSG00000135090


Database:KEGG pathway       Name:Adherens junction       ID:04520
C=73; O=6; E=0.49; R=12.31; rawP=9.85e-06; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104067 NA TJP1 tight junction protein 1 7082 ENSG00000104067
2  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
3  ENSG00000095637 NA SORBS1 sorbin and SH3 domain containing 1 10580 ENSG00000095637
4  ENSG00000135341 NA MAP3K7 mitogen-activated protein kinase kinase kinase 7 6885 ENSG00000135341
5  ENSG00000183230 NA CTNNA3 catenin (cadherin-associated protein), alpha 3 29119 ENSG00000183230
6  ENSG00000035403 NA VCL vinculin 7414 ENSG00000035403


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=8; E=1.34; R=5.99; rawP=6.54e-05; adjP=0.0008
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128591 NA FLNC filamin C, gamma 2318 ENSG00000128591
2  ENSG00000110092 NA CCND1 cyclin D1 595 ENSG00000110092
3  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
4  ENSG00000171791 NA BCL2 B-cell CLL/lymphoma 2 596 ENSG00000171791
5  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
6  ENSG00000035403 NA VCL vinculin 7414 ENSG00000035403
7  ENSG00000101608 NA MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 10627 ENSG00000101608
8  ENSG00000105971 NA CAV2 caveolin 2 858 ENSG00000105971


Database:KEGG pathway       Name:Arrhythmogenic right ventricular cardiomyopathy (ARVC)       ID:05412
C=74; O=5; E=0.49; R=10.12; rawP=0.0001; adjP=0.0010
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
2  ENSG00000183230 NA CTNNA3 catenin (cadherin-associated protein), alpha 3 29119 ENSG00000183230
3  ENSG00000198947 NA DMD dystrophin 1756 ENSG00000198947
4  ENSG00000170558 NA CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1000 ENSG00000170558
5  ENSG00000153956 NA CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 781 ENSG00000153956


Database:KEGG pathway       Name:Neurotrophin signaling pathway       ID:04722
C=127; O=6; E=0.85; R=7.07; rawP=0.0002; adjP=0.0018
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
2  ENSG00000134308 NA YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 10971 ENSG00000134308
3  ENSG00000171791 NA BCL2 B-cell CLL/lymphoma 2 596 ENSG00000171791
4  ENSG00000134313 NA KIDINS220 kinase D-interacting substrate, 220kDa 57498 ENSG00000134313
5  ENSG00000109458 NA GAB1 GRB2-associated binding protein 1 2549 ENSG00000109458
6  ENSG00000179295 NA PTPN11 protein tyrosine phosphatase, non-receptor type 11 5781 ENSG00000179295


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=6; E=0.92; R=6.51; rawP=0.0003; adjP=0.0023
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162409 NA PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 5563 ENSG00000162409
2  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
3  ENSG00000095637 NA SORBS1 sorbin and SH3 domain containing 1 10580 ENSG00000095637
4  ENSG00000109819 NA PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 10891 ENSG00000109819
5  ENSG00000187840 NA EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1978 ENSG00000187840
6  ENSG00000142875 NA PRKACB protein kinase, cAMP-dependent, catalytic, beta 5567 ENSG00000142875


Database:KEGG pathway       Name:Leukocyte transendothelial migration       ID:04670
C=116; O=5; E=0.77; R=6.45; rawP=0.0011; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
2  ENSG00000183230 NA CTNNA3 catenin (cadherin-associated protein), alpha 3 29119 ENSG00000183230
3  ENSG00000035403 NA VCL vinculin 7414 ENSG00000035403
4  ENSG00000101608 NA MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 10627 ENSG00000101608
5  ENSG00000179295 NA PTPN11 protein tyrosine phosphatase, non-receptor type 11 5781 ENSG00000179295


Database:KEGG pathway       Name:Adipocytokine signaling pathway       ID:04920
C=68; O=4; E=0.45; R=8.81; rawP=0.0011; adjP=0.0068
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162409 NA PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 5563 ENSG00000162409
2  ENSG00000096968 NA JAK2 Janus kinase 2 3717 ENSG00000096968
3  ENSG00000109819 NA PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 10891 ENSG00000109819
4  ENSG00000179295 NA PTPN11 protein tyrosine phosphatase, non-receptor type 11 5781 ENSG00000179295


Database:KEGG pathway       Name:Bacterial invasion of epithelial cells       ID:05100
C=70; O=4; E=0.47; R=8.56; rawP=0.0013; adjP=0.0073
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000183230 NA CTNNA3 catenin (cadherin-associated protein), alpha 3 29119 ENSG00000183230
2  ENSG00000035403 NA VCL vinculin 7414 ENSG00000035403
3  ENSG00000105971 NA CAV2 caveolin 2 858 ENSG00000105971
4  ENSG00000109458 NA GAB1 GRB2-associated binding protein 1 2549 ENSG00000109458


Database:KEGG pathway       Name:Hypertrophic cardiomyopathy (HCM)       ID:05410
C=83; O=4; E=0.55; R=7.22; rawP=0.0024; adjP=0.0124
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162409 NA PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 5563 ENSG00000162409
2  ENSG00000155657 NA TTN titin 7273 ENSG00000155657
3  ENSG00000198947 NA DMD dystrophin 1756 ENSG00000198947
4  ENSG00000153956 NA CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 781 ENSG00000153956


Database:KEGG pathway       Name:Prostate cancer       ID:05215
C=89; O=4; E=0.59; R=6.73; rawP=0.0030; adjP=0.0132
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
2  ENSG00000110092 NA CCND1 cyclin D1 595 ENSG00000110092
3  ENSG00000171791 NA BCL2 B-cell CLL/lymphoma 2 596 ENSG00000171791
4  ENSG00000146592 NA CREB5 cAMP responsive element binding protein 5 9586 ENSG00000146592


Database:KEGG pathway       Name:Dilated cardiomyopathy       ID:05414
C=90; O=4; E=0.60; R=6.66; rawP=0.0032; adjP=0.0132
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000155657 NA TTN titin 7273 ENSG00000155657
2  ENSG00000198947 NA DMD dystrophin 1756 ENSG00000198947
3  ENSG00000153956 NA CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 781 ENSG00000153956
4  ENSG00000142875 NA PRKACB protein kinase, cAMP-dependent, catalytic, beta 5567 ENSG00000142875


Database:KEGG pathway       Name:ErbB signaling pathway       ID:04012
C=87; O=4; E=0.58; R=6.88; rawP=0.0028; adjP=0.0132
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
2  ENSG00000113070 NA HBEGF heparin-binding EGF-like growth factor 1839 ENSG00000113070
3  ENSG00000109458 NA GAB1 GRB2-associated binding protein 1 2549 ENSG00000109458
4  ENSG00000187840 NA EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1978 ENSG00000187840


Database:KEGG pathway       Name:mTOR signaling pathway       ID:04150
C=52; O=3; E=0.35; R=8.64; rawP=0.0051; adjP=0.0186
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162409 NA PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 5563 ENSG00000162409
2  ENSG00000164327 NA RICTOR RPTOR independent companion of MTOR, complex 2 253260 ENSG00000164327
3  ENSG00000187840 NA EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1978 ENSG00000187840


Database:KEGG pathway       Name:Endometrial cancer       ID:05213
C=52; O=3; E=0.35; R=8.64; rawP=0.0051; adjP=0.0186
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
2  ENSG00000110092 NA CCND1 cyclin D1 595 ENSG00000110092
3  ENSG00000183230 NA CTNNA3 catenin (cadherin-associated protein), alpha 3 29119 ENSG00000183230


Database:KEGG pathway       Name:Inositol phosphate metabolism       ID:00562
C=57; O=3; E=0.38; R=7.88; rawP=0.0066; adjP=0.0227
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000078269 NA SYNJ2 synaptojanin 2 8871 ENSG00000078269
2  ENSG00000109452 NA INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8821 ENSG00000109452
3  ENSG00000138193 NA PLCE1 phospholipase C, epsilon 1 51196 ENSG00000138193


Database:KEGG pathway       Name:Colorectal cancer       ID:05210
C=62; O=3; E=0.41; R=7.25; rawP=0.0083; adjP=0.0271
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
2  ENSG00000110092 NA CCND1 cyclin D1 595 ENSG00000110092
3  ENSG00000171791 NA BCL2 B-cell CLL/lymphoma 2 596 ENSG00000171791


Database:KEGG pathway       Name:Cell cycle       ID:04110
C=124; O=4; E=0.83; R=4.83; rawP=0.0098; adjP=0.0304
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
2  ENSG00000134308 NA YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 10971 ENSG00000134308
3  ENSG00000110092 NA CCND1 cyclin D1 595 ENSG00000110092
4  ENSG00000166483 NA WEE1 WEE1 homolog (S. pombe) 7465 ENSG00000166483


Database:KEGG pathway       Name:Epithelial cell signaling in Helicobacter pylori infection       ID:05120
C=68; O=3; E=0.45; R=6.61; rawP=0.0107; adjP=0.0316
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104067 NA TJP1 tight junction protein 1 7082 ENSG00000104067
2  ENSG00000113070 NA HBEGF heparin-binding EGF-like growth factor 1839 ENSG00000113070
3  ENSG00000179295 NA PTPN11 protein tyrosine phosphatase, non-receptor type 11 5781 ENSG00000179295


Database:KEGG pathway       Name:Axon guidance       ID:04360
C=129; O=4; E=0.86; R=4.64; rawP=0.0112; adjP=0.0316
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
2  ENSG00000075223 NA SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 10512 ENSG00000075223
3  ENSG00000165410 NA CFL2 cofilin 2 (muscle) 1073 ENSG00000165410
4  ENSG00000185033 NA SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 10509 ENSG00000185033


Database:KEGG pathway       Name:Phosphatidylinositol signaling system       ID:04070
C=78; O=3; E=0.52; R=5.76; rawP=0.0155; adjP=0.0418
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000078269 NA SYNJ2 synaptojanin 2 8871 ENSG00000078269
2  ENSG00000109452 NA INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8821 ENSG00000109452
3  ENSG00000138193 NA PLCE1 phospholipase C, epsilon 1 51196 ENSG00000138193


Database:KEGG pathway       Name:Wnt signaling pathway       ID:04310
C=150; O=4; E=1.00; R=3.99; rawP=0.0185; adjP=0.0478
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
2  ENSG00000110092 NA CCND1 cyclin D1 595 ENSG00000110092
3  ENSG00000135341 NA MAP3K7 mitogen-activated protein kinase kinase kinase 7 6885 ENSG00000135341
4  ENSG00000142875 NA PRKACB protein kinase, cAMP-dependent, catalytic, beta 5567 ENSG00000142875




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).